CUX1 in leukemia: dosage matters

CUX1 in leukemia: dosage matters.

PU.1 and Haematopoietic Cell Fate: Dosage Matters

The ETS family transcription factor PU.1 is a key regulator of haematopoietic differentiation. Its expression is dynamically controlled throughout haematopoiesis in order to direct appropriate lineage specification. Elucidating the biological role of PU.1 has proved challenging. This paper will discuss how a range of experiments in cell lines and mutant and transgenic mouse models have enhanced...

Philosophy matters in brain matters

PURPOSE Although most neuroscientists and physicians would argue against Cartesian dualism, Descartes's version of the psyche/soma divide, which has been controversial since he proposed it in the seventeenth century, continues to haunt contemporary neurological diagnoses through terms such as functional, organic, and psychogenic. Drawing on my own experiences as a person with medically unexplai...

Claims and Jurisdictions in Medical Matters Disputes

Medical claims are all disputes that are somehow related to the medical and related matters so its subject is wide-ranging. These are civil, criminal and diciplinair medical cases, and due to the multy natures of such cases, we are likely to see numerous authorities to them. Furthermore, here expert medical expertise and expert opinion play an important role, but the rules are somewhat conflict...

RAS Transformation Requires CUX1-Dependent Repair of Oxidative DNA Damage

The Cut homeobox 1 (CUX1) gene is a target of loss-of-heterozygosity in many cancers, yet elevated CUX1 expression is frequently observed and is associated with shorter disease-free survival. The dual role of CUX1 in cancer is illustrated by the fact that most cell lines with CUX1 LOH display amplification of the remaining allele, suggesting that decreased CUX1 expression facilitates tumor deve...